Polygonum Cuspidatum Extract -Resveratrol Fine Powder High Density Granular CAS 501-36-0

• Customization: Available
• Certification: ISO, HACCP
• Assay Method: HPLC-MS, HPLC, UV
• Model NO.: SQ102
• Application Form: Tablet, Capsule
• Application: Health Care Products, Medicine
• State: Powder
• Extract Source: Polygonum Multiflorum
• Transport Package: Paper Drum
• Specification: 25kg/paper drum
• Trademark: SQbiotech
• Origin: China
• HS Code: 2932999099
• Production Capacity: 10000kg/Month

Product Description

Product Description

• Product Name: Resveratrol
• English Name: Resveratrol
• Plant Source: Polygonaceae family, perennial shrub-like herb Polygonum cuspidatum Sieb. et Zucc., dried rhizome;                                  Liliaceae family, Veratrum grandiflorum
• Synonyms: 3,5,4'-Trihydroxystilbene, 3,5,4'-Trihydroxy-trans-stilbene
• Molecular Formula: C14H12O3
• Molecular Weight: 228.25 g/mol
• Melting Point and Solubility: 253-255°C
• Appearance: White needle-like crystals
• Forms: Cis-resveratrol, trans-resveratrol, cis-resveratrol glucoside, and trans-resveratrol glucoside
• CAS Number: 501-36-0
• Physical and Chemical Properties: Colorless, tasteless needle-like crystals; poorly soluble in water (0.03 g/L), easily soluble in ethanol, chloroform, methanol, ether (50 g/L), and acetone. Exhibits fluorescence under 365 nm UV light and reacts with ferric chloride-potassium ferricyanide to produce a color reaction.
• Product Applications: Widely used in health supplements, dietary supplements, and cosmetics. Research shows resveratrol may support cardiovascular health, anti-aging, and disease prevention.

More information about Resveratrol in Polygonum Cuspidatum Extract

 

Resveratrol is a significant bioactive compound found in the extract of Polygonum cuspidatum.

 

I. Functions

 

1. Antioxidant Activity
   • Resveratrol is a potent antioxidant. It acts as a free - radical scavenger, effectively neutralizing harmful free radicals such as superoxide anions, hydroxyl radicals, and peroxyl radicals. These free radicals are generated during normal cellular metabolism and can also be induced by external factors like ultraviolet radiation and pollution. By eliminating these free radicals, resveratrol helps protect cells from oxidative damage, which is associated with various diseases including premature aging, cancer, and cardiovascular disorders.
   • It can also upregulate the body's endogenous antioxidant defense system. For example, it can enhance the activity of antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH - Px). These enzymes play a crucial role in maintaining the redox balance within cells.
2. Anti - inflammatory Effects
   • Resveratrol has the ability to suppress the inflammatory response. It inhibits the activation of nuclear factor - kappa B (NF - κB), a key transcription factor that regulates the expression of many pro - inflammatory genes. By blocking NF - κB activation, it reduces the production of inflammatory mediators such as cytokines (e.g., interleukin - 1β, interleukin - 6), chemokines, and prostaglandins.
   • This anti - inflammatory property makes it potentially beneficial for treating chronic inflammatory diseases like rheumatoid arthritis, inflammatory bowel disease, and asthma. In animal models of arthritis, resveratrol has been shown to reduce joint swelling and pain by modulating the inflammatory cascade.
3. Cardiovascular Protection
   • Resveratrol can improve vascular function. It promotes vasodilation by increasing the bioavailability of nitric oxide (NO). NO is a signaling molecule that relaxes smooth muscle cells in blood vessels, leading to widening of the blood vessels and improved blood flow. This helps in reducing blood pressure and preventing hypertension.
   • It also has anti - platelet and anti - thrombotic activities. Resveratrol inhibits platelet aggregation, which is a crucial step in the formation of blood clots. By preventing excessive platelet aggregation, it reduces the risk of thrombosis and related cardiovascular events such as myocardial infarction and stroke.
4. Anti - cancer Properties
   • Resveratrol shows potential anti - cancer activities. It can induce cell cycle arrest in cancer cells, preventing their uncontrolled proliferation. For example, it can block the cell cycle at the G1/S or G2/M checkpoints, depending on the type of cancer cell.
   • It also triggers apoptosis, or programmed cell death, in cancer cells. This is achieved through the activation of various apoptotic pathways, such as the extrinsic (death receptor - mediated) and intrinsic (mitochondria - mediated) pathways. Additionally, resveratrol can inhibit angiogenesis, the process by which tumors develop a blood supply. By cutting off the blood supply to tumors, it restricts their growth and metastasis.

 

II. Applications

 

1. In the Pharmaceutical Industry
   • Resveratrol is being investigated for its potential use in the development of new drugs for various diseases. In cancer treatment, it may be used as an adjuvant therapy to enhance the efficacy of existing chemotherapeutic agents or to target specific cancer - related pathways. For example, in combination with drugs that target cell cycle regulation, resveratrol could potentially provide a more comprehensive approach to cancer treatment.
   • In the treatment of cardiovascular diseases, it could be formulated into drugs aimed at improving vascular health and reducing the risk of thrombotic events. Clinical trials are underway to evaluate its safety and efficacy in treating hypertension and atherosclerosis.
2. In the Cosmetic Industry
   • Due to its antioxidant and anti - aging properties, resveratrol is a popular ingredient in anti - aging cosmetics. It is added to creams, serums, and lotions to protect the skin from oxidative damage caused by environmental factors such as UV radiation and pollution. It can help reduce the appearance of wrinkles, improve skin elasticity, and maintain a healthy skin tone.
3. In the Dietary Supplement Industry
   • Resveratrol is widely available as a dietary supplement. People take it to potentially benefit from its antioxidant and anti - inflammatory effects. It is often promoted for its purported health - promoting properties such as improving heart health, enhancing immunity, and providing anti - aging benefits. However, it's important to note that the efficacy and safety of high - dose resveratrol supplements are still under investigation, and consumers should follow the recommended dosage and consult a healthcare provider before use.                                         
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